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E5627
Sigma
Erythropoietin human
recombinant, expressed in CHO cells, lyophilized powder, cell culture tested, ~100,000 units/mg protein
| Synonym: | EPO |
| CAS Number: | 11096-26-7 |
| EC Number: | 234-317-2 |
| MDL number: | MFCD00131025 |
Description
| Analysis Note | The biological activity is assayed in tissue culture using mouse fetal liver cells. |
| Biochem/physiol Actions | Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation. |
| Physical form | Lyophilized from 40 mM sodium citrate, pH 7.0, and 170 mM sodium chloride. |
Properties
| recombinant | expressed in CHO cells |
| form | lyophilized powder |
| suitability | cell culture tested |
| Gene Information | human ... EPO(2056), EPOR(2057) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
| RTECS | KF5885000 |
References
| reference | Miyake, T., et al., Purification of human erythropoietin. J. Biol. Chem. 252, 5558, (1977) |
| Dordal, M.S., et al., The role of carbohydrate in erythropoietin action. Endocrinology 116, 2293, (1985) | |
| Davis, J.M., et al., Characterization of recombinant human erythropoietin produced in Chinese hamster ovary cells. Biochemistry 26, 2633, (1987) | |
| Bailey, S.C., et al., Erythropoietin induces cytosolic protein phosphorylation and dephosphorylation in erythroid cells. J. Biol. Chem. 266, 24121, (1991) | |
| Hanspal, M., et al., Erythropoietin enhances the assembly of α, β spectrin heterodimers on the murine erythroblast membranes by increasing β spectrin synthesis. J. Biol. Chem. 266, 15626, (1991) | |
| Merck | Merck 13,3722 |
